When AIP was combined with LDL-C, the best cut-off value for predicting acute myocardial infarction was 0.756107, with a sensitivity of 79%, a specificity of 74%, and an AUC of 0.819 (95% CI: 0.759–0.879, P < 0.001). The gene discussed is AIP; the disease is myocardial infarction.