PRKN and myocardial infarction: Studies indicate that irisin-activated optic atrophy 1 (OPA1) could increase PINK1/Parkin-mediated mitophagy, prevent myocardial cell damage after myocardial infarction, and reverse cardiac dysfunction caused by ischemia, playing a pivotal role in maintaining myocardial cell vitality and mitochondrial function following myocardial infarction (12).