In some cases these may be due to (clonal expansion of) somatic mutations within the epigenetic modifying enzymes, Tet2 and Dnmt3a. Genetic editing, to reverse mutations known to be causal in the development of atherosclerosis represents a promising stem cell-based therapeutic strategy in the elusive struggle to reverse the progression of atherosclerosis. This evidence concerns the gene DNMT3A and atherosclerosis.