The key feature of vascular proliferation diseases is the abnormal proliferation and migration of VSMC, including atherosclerosis, restenosis after vascular injury and vascular wall hypertrophy caused by hypertension.(10–12) Resistin is an adipokine mainly expressed in human monocyte/macrophage lineage cells, which is closely related to cardiovascular diseases and adverse clinical outcomes (13). This evidence concerns the gene RETN and cardiovascular disorder.