SLC5A2 and gout: The incidence rate of gout was significantly lower in patients initiated with a SGLT2 inhibitors with a hazard ratio of 0.58 (0.44 to 0.75).The current hypothesis on the mechanisms whereby SGLT2 inhibitors lower serum uric acid is that glucose promotes urinary uric acid excretion through the high urine flow rate induced by the glycosuria.