High expressions of serum IGFBP7 protein were also found in high-grade soft tissue sarcoma, colorectal cancer, esophageal squamous cell carcinoma, and esophagogastric junction adenocarcinoma (Benassi et al., 2015; Huang et al., 2019; Liu et al., 2020; Qiu et al., 2020). This evidence concerns the gene IGFBP7 and colorectal cancer.