As shown in Fig. 3C, using the same cutoff value of 1.515 ng/ml, in the independent validation cohort, IGFBP7 could identify gastric cancers with an AUC value of 0.758 (95% CI [0.664–0.852]), a sensitivity of 34.5% (95% CI [22.6–48.7]), and a specificity of 85.5% (95% CI [72.8–93.1]). This evidence concerns the gene IGFBP7 and gastric cancer.