ACHE and Alzheimer disease: Currently, numerous monomers with impressive chemical structures showing bioactivities of glycogen synthase kinase-inhibitory, acetylcholinesterase-inhibitory, anti-pathogenic fungi, anti-tumour and anti-Alzheimer’s disease (AD) activities, such as Isopyrrolonaphthoquinone, Biscogniphthalide, Eudesmanolide,Biscognienyne C, Biscognienyne D, Biscognienyne F and Dimericbiscognienyne A, have been isolated from this genus (Wu et al., 2016; Nguyen et al., 2018; Liu et al., 2019; Zhao et al., 2017, 2021a).