Intricately connected to internal environmental homeostasis, ferroptosis partakes in diverse tumor progression stages and activates various tumor suppressors, such as p53 and BRCA1-associated protein 1 (BAP1) (Jiang et al., 2015; Zhang et al., 2018; Chen et al., 2021; Zhao, Yang & Yang, 2022). The gene discussed is TP53; the disease is neoplasm.