AKT1 and cancer: Deregulated of PI3K/AKT/mTOR and Raf/MEK/Erk signaling pathways were observed simultaneously in human cancer cells (Wilhelm et al., 2004; Will et al., 2014), and the subsequent excessive production of ROS has been reported to be associated with apoptosis and autophagy (Niu et al., 2015a; Pan et al., 2015).