HIF1A and neoplasm: Cardamonin protected the heart from oxidative damage and inflammatory injury by activating Nrf2-related cytoprotective system in cardiac muscle cells (Qi et al., 2020), whereas cardamonin suppressed tumor cell growth by inducing oxidative stress through NF-κB/mTOR and HIF-1α pathways (Jin et al., 2019; Ruibin et al., 2020).