Similarly, the highly selective and irreversible MAO-A inhibitor clorgyline demonstrated antidepressant effects in human, however, it is not used clinically because of dietary interactions (Fig. 1).14l-Deprenyl, the irreversible MAO-B inhibitor is approved for the treatment of Parkinson disease with trade name Selegiline.15 Currently, several cholinesterase inhibitors, for example donepezil, neostigmine, galantamine and others, are used for the treatment of AD, myasthenia gravis and other disorders.13 The gene discussed is MAOB; the disease is Alzheimer disease.