According to the optimal cut-off values for RNF43 and YAP (Figs. 2b and 8c), ccRCC patients were divided into four groups (RNF43high YAPlow, RNF43low YAPhigh, RNF43low YAPlow, and RNF43high YAPhigh). Here, RNF43 is linked to nonpapillary renal cell carcinoma.