Furthermore, higher expression of TEAD1 and YAP target genes, including AXL, ANKRD1, AMOTL1, CYR61, and CTGF, was observed in ccRCC cells with RNF43 knockdown than in RNF43-overexpressing ccRCC cells (Figs. 5c and 5d; Suppl. This evidence concerns the gene AMOTL1 and nonpapillary renal cell carcinoma.