AKT1 and cancer: As there is evidence to indicate the occurrence of both pathways to bring out a total anti-cancer effect by chemotherapeutic compound [32,33], it can be postulated that FPMXY-14 would have acted in both ways to attenuate the mitochondrial potential and Akt signalling cascade of Caki-1 and A498 cells, ultimately making them bioenergy deficient and subsequently undergo apoptosis.