The relation of the gene to FLT3 mutational status as one of the most important poor prognostic factors in AML was observed also by Latuske et al., who found that overexpression of GLI-1 confers an adverse prognosis to AML patients as it was positively correlated with a mutated FLT3 [19]. The gene discussed is GLI1; the disease is acute myeloid leukemia.