A study on Alzheimer’s disease showed that EA at GV20 and EX-HN3 acupoints could effectively improve the learning and memory of mice and reduce the expression of interleukin-1β (IL-1 β), interleukin-6 (IL6), and tumor necrosis factor-α (TNF-α) (90). Here, TNF is linked to early-onset autosomal dominant Alzheimer disease.