Previous studies have developed ways to sensitize 5-FU-resistant tumor cells to 5-FU [12,28–30], and KGM is indicated to enhance the sensitivity of HCC cells to 5-FU by facilitating apoptosis and hindering the proliferation potential by inactivating the AKT pathway and upregulating p53 levels [14]. The gene discussed is TP53; the disease is hepatocellular carcinoma.