TWIST1 and cancer: Such resistance has been linked to EMT-mediators, which are specific transcription factors (Zinc finger protein SNAI1 (Snail), Twist-related protein 1 (Twist), Zinc Finger E-Box Binding Homeobox 1 (Zeb1)), posttranscriptional regulators (miRNAs), or posttranslational regulators (such as Casein kinase I (CK1)) in a wide variety of cancer types [54–59] and attributed to different mechanisms including elevated expression of ABC transporters, evading apoptosis signaling pathways, and decreased cell proliferation [60].