The other studies in the literature stated that BC cells became sensitive to PAX treatment through the regulation of the miR-1299/CDK8 (Cyclin Dependent Kinase 8) axis as a result of the downregulation of circ_0006528 [98], and the regulation of miR-1286/HK2 axis as a consequence of the downregulation of circHIPK3 [99]. This evidence concerns the gene CDK8 and breast cancer.