CD274 and hypothyroidism: For example, nivolumab is easy to cause endocrine adverse reactions; arthritis, pneumonia and liver adverse reactions are common in pembrolizumab therapy (44), domestic camrelizumab is easy to cause reactive skin capillarosis, and PD-L1 inhibitor atezolizumab is more likely to cause hypothyroidism, nausea, vomiting and other symptoms (38).