The most significant modifications were found when interrogating populations of NK cells, where there was a significant increase in NKp46-positive area in both tumor models after CaEP with p.t. IL-12 GET (group 13) and ECT/BLM with i.t. and p.t. IL-12 GET (group 26) and was concentrated in the proximity of the necrotic area (Figures 6B, 7B, 9C, G). Here, NCR1 is linked to neoplasm.