One patient of group 3 (11%) and 6 of group 4 (35%) had a severe reduction in CD4+ (<200 cells/mm3) and/or naïve CD4+ naive (20 cells/mm3), thus fulfilling the criteria for the diagnosis of Late-Onset Combined Immunodeficiency (LOCID) (51). This evidence concerns the gene CD4 and severe combined immunodeficiency.