Besides this trial, several other studies have assessed the factors/biomarkers associated with occurrence of severe CRS which include pre-treatment tumor burden, CAR-T cell dose, CD4/CD8 CAR-T cell ratio, peak CAR-T cell in vivo expansion, and the measurement of serum cytokine levels at specific timepoints post-CAR-T infusion (61, 62). This evidence concerns the gene CD8A and neoplasm.