➢ Inhibitory CARs (iCARs) where the T cell expresses two CARs – one that contains a stimulatory and costimulatory domain and binds the tumor specific antigen, and the other one that is linked to an inhibitory domain (Programmed cell death protein -1 (PD-1)/Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4)) and specific to an antigen expressed on the normal healthy cells. The gene discussed is CTLA4; the disease is neoplasm.