Pyrexia, hypotension, increased aspartate aminotransferase (AST), chills, increased alanine aminotransferase and sinus tachycardia. Grade 3 or higher events associated with CRS included increased AST and ALT, hyperbilirubinemia, hypotension, pyrexia, hypoxia, respiratory failure, acute kidney injury, disseminated intravascular coagulation, HLH/MAS, angina pectoris, supraventricular and ventricular tachycardia, malaise, myalgias, increased-Creactive protein, ferritin, blood alkaline phosphatase and gamma-glutamyl transferase. The gene discussed is GPT; the disease is malaise.