Besides MHC-II, other ligands of LAG-3 include galectin-3 found on tumor and tumor stromal cells, liver sinusoidal endothelial cell lectin (LSECtin) which is expressed on liver and melanoma cells, and fibrogen-like protein 1 (FGL1) secreted from hepatocytes and tumor cells (144–146). Here, LGALS3 is linked to neoplasm.