CD40LG and neoplasm: While immature dendritic cells were driven to be pro-inflammatory by HERA-CD40L as determined by surface marker expression and IL-12 production (41) (Figure 2C), macrophages were also repolarized from M2 anti-inflammatory/pro-tumor macrophages (M2a and M2d demonstrated very similar responses, suggesting a high comparability between M2 macrophage subtypes) to pro-inflammatory M1 macrophages in response to HERA-CD40L (42) (Figure 4).