HIF1A and hepatocellular carcinoma: USP29 inhibits ubiquitin-mediated proteasomal degradation of the Cdc25A protein by removing its polyubiquitination signal (10).USP29 directly deubiquitinates and stabilizes HIF1α, promotes its transcriptional activityand causes sorafenib resistance in hepatocellular carcinoma cells by increasing aerobic glycolysis (14).