In tumor studies of liver, stomach, and colon cancers, USP29 is also essential during tumorigenesis and chemotherapy resistance by stabilizing the expression and function of various substrate proteins, such as Cdc25A (Cell division cycle 25A), Snail, MYC, and HIF1α, through deubiquitination, thereby affecting the proliferation, invasion, and tumor cell migration (10–15). The gene discussed is HIF1A; the disease is neoplasm.