ALOX5 and myeloid sarcoma: KD was reported to influence the expression of enzymes involved in the inflammatory response in MS: KD inhibited the systemic expression of the enzymes cyclooxygenase 1 (COX1), COX2, and arachidonate 5-lipoxygenase (ALOX5), which are involved in the biosynthesis of pro-inflammatory eicosanoids and implicated in demyelination and inflammation in MS (149).