Notably, the most highly identified gene associated with sepsis, Haptoglobin (HP) an acute-phase marker of red blood cell (RBC) destruction, was found in only 34 of the 103 gene sets (33.0%) surveyed, perhaps reflecting the variability in time of sampling during a patient’s disease, patient age (neonate/pediatric/adult/senior) and other experimental variables, as well as the rather low accuracy methodology (microarrays) used for almost 60% of studies. The gene discussed is HP; the disease is Sepsis.