While neutrophil degranulation is one notable pathway we observed, several other pathways were enriched (e.g., IL-10, PD-1 signaling, etc.), and can be further scrutinized for their role in sepsis and specifically targeted, e.g., IL-10 signaling inhibitors (21) and checkpoint inhibitors of PD-1 signaling (22). Here, IL10 is linked to Sepsis.