As expected, when using the cis-eQTL instruments and similarly estimated by IVW, most of findings from our main analysis including IL-1ra, MCSF were replicated, yet the MIF (OR: 1.13, 95% CI: 1.06-1.22, P: 4.15E-04) maintained notable significant relationship with CAD risk. This evidence concerns the gene MIF and coronary artery disorder.