Once again, the effects were dependent on the skin type origin of the isolate, those from NH healthy skin induce OVOL1 whereas strains from atopic skin induce STAT6. In the context of AD, it was recently shown that the high level of IL-4 and IL-13 induce the decrease of FLG-1 via induction of STAT6 (73). The gene discussed is STAT6; the disease is Alzheimer disease.