CXCL8 and Alzheimer disease: A test on reconstructed 3D skin model was then performed to characterize the effects on a skin tissue, using representative isolates of each group chosen based on their capacity to induce cytotoxicity and IL-8 production on NHEK: NH skin (1191, 52B), H skin (50D) and lesional AD skin (45A6, 44) as well as the reference strain ATCC 12228.