GNAS and pancreatic intraductal papillary-mucinous neoplasm: By analyzing GNAS mutation in circulating cell‐free DNA (cfDNA) from 57 patients with pancreatic cystic neoplasms (PCNs) (including 34 IPMN patients), Hata et al. [69] found that the positive rate of GNAS mutation in cfDNA was significantly higher in IPMN patients than in other PCN patients (32% vs. 0%, p = 0.002).