TEK and neoplasm: In addition, the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of Rapamycin (mTOR) (PI3K/Akt/mTOR) pathway mediated by Ang1/Ang2-Tie2 is the main channel involved in TEMs-related tumor micro angiogenesis and immunosuppressive microenvironment.