In conclusion, SHP-2 in TEMs suppressed the activation or phosphorylated-Tie2 and consequently deactivated down-stream of PI3K-Akt-mTOR and resulted in the inhibited expression of angiogenic factor: VEGF, COX-2, MMPs, and eventually protect the tumor angiogenesis in CRC. Here, PTPN11 is linked to colorectal carcinoma.