It indicated that the deletion of SHP-2 promotes the activation of the Ang/Tie2-PI3K/Akt/mTOR pathway in the liver tissue of mice with CRC liver metastasis, indicating the SHP-2 dephosphorylated Tie2, a receptor tyrosine kinases (RTK), which is activated by angpt1/2 directly and results in the phosphorylated form of Tie-2 [44,45]. This evidence concerns the gene NTRK1 and colorectal carcinoma.