Firstly, through the construction of SHP-2-deficient mouse models of CRC liver metastases, it was found that specific SHP-2-deficient mice had significantly more metastatic cancer nodules on the liver surface than wild-type mice, and a high-level expression of p-Tie2 was observed in the liver tissue of SHP-2MAC-KO + planted tumor mice. This evidence concerns the gene PTPN11 and cancer.