The results of the present study showed that after CRC liver metastasis, the SHP-2MAC-KO + planted tumor group obtained significantly higher levels of p-Tie2, p-PI3K, p-Akt, p-mTOR, VEGF, COX-2, MMP2, MMP9 in the liver tissue than the SHP-2WT + planted tumor group. The gene discussed is VEGFA; the disease is neoplasm.