These studies directly tested the differences of functions or activation of transduction signals of primary TEMs from hepatic metastatic colorectal cancer (CT26 cells) in SHP-2WT + planted tumor group, the SHP-2MAC-KO + planted tumor group as the experiments in vivo (Figs. 3 and Suppl. The gene discussed is NR0B2; the disease is metastatic colorectal cancer.