Hence, in vitro, firstly the primary TEMs, from hepatic CT26 tumor tissues were cultured and stimulated with Angpt1/2 to activate the Tie receptor in TEMs, which were carried out to examine the mediating role of the down-stream signals of Tie2: PI3K/Akt/mTOR pathway in the influence of macrophages’ SHP-2-cKO on CRC liver metastasis of mice and the influence of SHP-2 on tumor microvascular remodeling. This evidence concerns the gene AKT1 and neoplasm.