EGF and neoplasm: Immunosuppressive inflammatory cells secrete MMPs to promote the matrix remodeling outside tumors [42], secrete pro-angiogenic factors including VEGF, transforming growth factor-β (TGF-β), and EGF, break the balance and homeostasis of blood vessels in the tumor tissue and enhance the sprouting and junctions of peripheral vessels, thus creating favorable conditions for the tumor micro-angiogenesis [7,43].