In the context of PD, physical exercise improved motor function, reduced cognitive impairment, and modulated the expression of L-DOPA, cAMP-responsive element binding protein 1 (CREB1), and RPTOR independent companion of MTOR complex 2 (RICTOR), genes involved in mitochondrial function and dopamine signaling in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice (Aguiar et al., 2016; Klemann et al., 2018). Here, CREB1 is linked to Cognitive impairment.