AV-001 is a synthetic Angiopoietin-1 mimetic and a clinical candidate version of Vasculotide, previously reported in a model of ischemic stroke in diabetic rats to significantly improve stroke outcome and neurological function by reducing neuroinflammation and blood brain barrier leakage in the ischemic penumbra (Venkat et al., 2018, 2021). This evidence concerns the gene ANGPT1 and ischemic stroke.