RECK and neoplasm: Yang et al. (2017) by RT-qPCR and Western blotting clearly demonstrated that casticin increased the mRNA and protein levels of the tumor suppressor gene “reversion-inducing-cysteine-rich protein kazal (RECK) motif” in MGC803 gastric cancer cells in a dose-dependent manner, and such evidence was associated by the authors to a casticin-induced decrease of RECK promoter methylation levels by 31%, global cellular DNA methylation levels by 39%, and nuclear methylation activity by 71.6%.