To test if increased central gain occurs in AD mouse models, we performed auditory tests in 5xFAD and APP/PS1 mice at similar ages (5xFAD at 12 months of age and APP/PS1 at 13 months of age), by which time both of the strains have significant plaque accumulation (Jankowsky et al., 2004; Oakley et al., 2006). The gene discussed is APP; the disease is Alzheimer disease.