STAT3 and cancer: Interestingly, the high-risk score group also comprised significant enrichment of unfavorable cancer-related hallmark gene sets (Fig. 8D), such as “ANGIOGENESIS”, “E2F_Target”, “IL2_STAT5 signaling”, “IL6_JAK_STAT3 signaling”, “MTORC1 signaling”, “MYC_TARGETS_V1” and “PI3K_AKT_MTOR signaling”.