Furthermore, significant expression differences of APOE were observed between tumor and normal tissues of GBM, Brain lower grade glioma (LGG), Lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), TGCT, Skin cutaneous melanoma (SKCM), and Thymoma (THYM) (Fig. 1B, p < 0.001). This evidence concerns the gene APOE and glioblastoma.