Olaparib reduced cell viability while at the same time inducing autophagy in BRCA1 mutant (SUM-149PT), BRCA2 mutant (HCC-1428), as well as MDA-MB-231 cell lines with shRNA-mediated BRCA1 or BRCA2 knockdown. The gene discussed is BRCA1; the disease is hepatocellular carcinoma.