Moreover, TCF20 can also act on estrogen (ER) and androgen (AR) receptors to play a role in circadian rhythm, and changes in TCF20 activity may be linked with sleep disorder, hyperactivity, anxiety, obsessive-compulsive disorder, and overgrowth, etc (Vetrini et al., 2019). This evidence concerns the gene TCF20 and obsessive-compulsive disorder.