VCP and amyotrophic lateral sclerosis: Regarding ALS, the frequency of VCP mutations in familial ALS patients, young-onset ALS patients (age of onset ≤45), and sporadic ALS patients are up to 2%, 3.7%, and 0.4%, respectively (González-Pérez et al., 2012; Johnson et al., 2010; Koppers et al., 2012; Deng et al., 2019; Abramzon et al., 2012).