Another missense variant at the same residue (NM_007126.5, c.266G>A; p.Arg89Gln) in the VCP gene has been reported in a Chinese patient with young-onset ALS, who died of respiratory failure 5 months after the onset of initial symptoms (Deng et al., 2019). The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.