INS and diabetes mellitus: Other potential drugs/targets, such as catalpol (a natural product isolated from the root of rehmannia glutinosa), thioredoxin‐interacting protein (TXNIP, a cellular redox regulator upregulated in diabetes),665 and transient receptor potential vanilloid 4 (TRPV4, a Ca2+‐permeable nonselective cation channel)666 have been reported to be involved in the development of T2DM, including but not limited to affecting insulin production and secretion,667 β cell function,143 IR,668 and glucose homeostasis.665, 669