TGFB1 and renal fibrosis: Accordingly, numerous approaches blocking TGFβ signaling, including TGFβ neutralizing antibodies, antisense TGFβ oligodeoxynucleotides, soluble human TGFR2, and specific inhibitors to TGFR1 kinases can effectively halt the progression of renal fibrosis and DN.537, 538, 542