For example, it has shown that high glucose can trigger the JAK/STAT signaling cascade to stimulate excessive proliferation of glomerular mesangial cells and aggravate DN,543 and the small‐molecule inhibitor of JAK/STAT, baricitinib, has been demonstrated to decrease albuminuria in patients with T2DM and DN.544. The gene discussed is SOAT1; the disease is liver dysplastic nodule.