Besides, IL‐6 is able to suppress glucose transport by affecting adiponectin and GLUT4,484 repress lipogenesis by inhibiting PPARγ,485 and stimulates lipolysis by activating AMPK in the adipose tissue,486 which may link the IL‐6 pathway to the progression of IR and T2DM. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.