GK and type 2 diabetes mellitus: Interestingly, these potential drugs target a number of key receptors, vital enzymes, or ion channels, such as glucokinase (GK) activators, G‐protein‐coupled receptor 40 (GPCR40), GLP‐1 receptor (GLP‐1R), and so on, which are involved in numerous signaling pathways associated with T2DM.9