Our data confirmed that intramyocardial Tx inhibited sarcoplasmic reticulum calcium leakage by lowering PLB and CAMK II expression and increasing SERCA2α expression to prevent arrhythmia, and the stimulating effect of intramyocardial Tx based on Kv1.5 may be a potential physiological advantage for regulating myocardial excitability. Here, PLN is linked to Arrhythmia.