In children with ERA who presented to our hospital, after completing the relevant inflammatory indicators (CRP, ESR, TNF-α) and MRI examination, the results showed high inflammatory indicators and poor MRI results; thus, conventional disease-modifying antirheumatic drugs (cDMARDs) combined with biologic disease-modifying antirheumatic drugs (bDMARDs) were usually chosen as the preferred treatment plan. Here, ESR1 is linked to enthesitis-related juvenile idiopathic arthritis.