There are also related clinical trials found that air pollutants and ABCC2, CYP1A1, CYP2B6, CYP2C19 and other genes between the gene-environment interaction effect, or by up-regulating miRNA to reduce cardiovascular-related gene expression, leading to abnormal expression of related genes, leading to the occurrence of congenital heart disease (24, 25). This evidence concerns the gene ABCC2 and congenital heart disease.