ERBB2 and cancer: Moreover, has_circ_0000069 levels were higher in different cancer cells BT549 (ER/PR/HER2-negative), MCF-7 (ER+), SK-BR-3 (HER+), T47D (ER+), MDA-MB-231 (ER/PR/HER2-negative), than normal breast cell MCF-10A (p < 0.05, Fig. 1B).