Low expression of miR-1294 can up-regulate the expression of downstream protein-coding genes microtubule nucleation factor (TPX2) [34], IGF1R [30], MYC proto-oncogene, bHLH transcription factor (c-Myc) [33,35] and TRL4, TRL6, TRL8, TRL9 [35], enolase 1 (ENO1) [13], thereby promoting the proliferation of various tumor cells. The gene discussed is ENO1; the disease is neoplasm.