These ceRNA/miRNA/PCG signaling axes that can promote tumor cell invasion and migration include circEYA3/miR-1294/c-Myc in PDAC [17], circ_0023984/miR-1294/c-Myc in ESCC [10], circCAMSAP1/miR-1294/GRAMD1 [21] and circ_0000854/miR-1294/IRGQ [23] in HCC, lncKRT16P2/miR- 1294/epidermal factor receptor (EGFR) in LSCC [8], lncTUG1/miR-1294/PLK1 in EC [7], circCDK17/miR-1294/YWHAZ in CC [27], circPLK1/miR-1294/HMGA1 in NSCLC [25] and MPM [24], and circSHKBP1/miR-1294/PKM2 in NSCLC [26]. The gene discussed is PKM; the disease is cholangiocarcinoma.