PIM1 and cancer: Among them, five target genes (c-Myc, IGF1R, AKT, fibroblast growth factor 1 (FGFR1), and pim-1 proto-oncogene, serine/threonine kinase (PIM1)) are involved in the regulation of the PI3K/AKT/mTOR, RAS, JAK/STAT signaling pathways (Fig. 4), thereby affecting the proliferation, apoptosis, invasion, and progression of cancer cells.