APBA2, the amyloid ß precursor protein binding A2 (aka X11ß, MINT2), is principally recognized for its role in synaptic vesicle exocytosis and its ability to stabilize amyloid precursor protein (APP), and is considered part of the genetic signature of Alzheimer's disease in Down syndrome [39]. This evidence concerns the gene APBA2 and early-onset autosomal dominant Alzheimer disease.