In the human diseased hearts, the RNA-sequencing data from human failing hearts with dilated cardiomyopathy (DCM) (GEO accession no: GSE29819) showed that the mRNA level of Piezo1 was up-regulated in the failing heart, while Piezo2 expression and other key ion channels remained unchanged (Fig. 1B and Fig. S1A). This evidence concerns the gene PIEZO1 and familial dilated cardiomyopathy.