PIEZO1 and myocardial infarction: Assessed by echocardiography, cardiac Piezo1 deletion showed a protective role on cardiac function as evidenced by the slight decrease of ejection fraction (EF) from 36.43% ± 4.44% to 31.31% ± 5.73% between the 3rd day to the 6th week after MI, while EF prominently declined from 33.04% ± 2.69% to 18.64% ± 2.73% in the Piezo1fl/fl group (Fig. 2D and E and Table S3).