SCN5A and Arrhythmia: However, Piezo1 deletion did not alter the expression of key ion channels in action potential generation and gap junction, including Nav1.5 (SCN5A), Cav1.2 (CACNA1C), Kir6.2 (KCNJ11), Kv7.1(KCNQ1), and connexin43 (GJA1) (Fig. 5D and Fig. S3A to D), but affected the sensitization of the ryanodine receptor (RyR2), which may result in arrhythmias [23].