The transcriptional expressions of Cxcl1, Cxcl2, Il-1β, Il-1α, S100A8, S100A9, Il-6, and Vegf were significantly decreased in skin lesions of K14.Bsgfl/fl mice (Fig. 1D), indicating the proinflammatory role of the epidermal expression of CD147 in psoriasis. This evidence concerns the gene IL1A and psoriasis.