Table 2 and Fig. 2 reveal that gene fold expression of miR-34a, BRCA1, BRCA2, and p53 is significantly up-regulated (p < 0.001) in BC with +ve ER, PR, and HER-2/neu compared to −ve ER, PR, and HER-2 before and after chemotherapy in BC with +ve ER, PR, and HER-2. Here, ESR1 is linked to breast cancer.