RNF43 and colorectal carcinoma: Interestingly, 96% of CRC patients have mutations in WNT (Wingless-type)/CTNNB1 (β-Catenin) signaling pathway components such as APC (adenomatous polyposis coli) (79%), CTNNB1 (8%), RNF43 (ring Finger protein 43) (9%) [2].