In contrast to the important role of WNT signaling in promoting tumor cell migration and invasion in CRC [10,11], knockdown of LSM12 not only effectively decreased cell migration (Fig. 2D, p < 0.001), but also strongly reduced cell invasion in the two CRC cell lines (Fig. 2E, p < 0.01 or p < 0.001). This evidence concerns the gene LSM12 and neoplasm.