Although the accumulated evidence indicate that CTNNB1-LEF1-TCF1 transcriptional target genes, such as MDR1 (multidrug resistance protein 1), Survivin, and MMP7 (matrix Metallopeptidase 7), act as chemoresistance factors in CRC [12,24–26], it is unclear whether inhibition of WNT signaling alone can achieve the therapeutic effect of CRC. This evidence concerns the gene ABCB1 and colorectal carcinoma.