However, other evidence suggest that AXIN1 (axis inhibition proteins 1) deubiquitin ligase USP44 (ubiquitin-specific peptidase 44) and LRP6 (low-density lipoprotein receptor-related protein 6) antagonist VSTM2A (V-set and transmembrane domain containing 2A) induce apoptosis of CRC cells and inhibit the growth of CRC by inactivating WNT signaling [27,28]. Here, LRP6 is linked to colorectal carcinoma.