SIVA1 and neoplasm: We also found that PCBP1 expression in the MKN-28/VCR-shRNA-Siva-1 group was significantly lower than that in the MKN-28/VCR-shRNA-NC group and MKN-28/VCR group (Figs. 5D and 5F) The mean percent of TUNEL-positive tumor cells was significantly higher in grafted tumors from the MKN-28/VCR-shRNA-Siva-1 group than in those from mice in the MKN-28/VCR-shRNA-NC and MKN-28/VCR (p < 0.05) groups (Figs. 5D and 5G), which revealed a significantly higher apoptosis rate in the Siva-1 knockdown group.