P2RY12 and Stroke: P2Y12 inhibitors can therefore be administered to aspirin-allergic or intolerant patients alone [23].When protamine is administered, aspirin-ticagrelor is associated with a reduced risk of stroke/death (1.5% vs. 3.9%; RR: 0.38) and bleeding (3.0% vs. 2.6%; RR: 1.1) complications following CAS compared to aspirin-clopidogrel.